Ninety-one percent of patients in each group received palbociclib (Ibrance, Pfizer) as the CDK4/6 inhibitor. Researchers randomly assigned patients to either first-line treatment with a nonsteroidal aromatase inhibitor plus a CDK4/6 inhibitor of physician’s choice, followed upon progression by fulvestrant, or first-line treatment with a nonsteroidal aromatase inhibitor, followed upon progression by fulvestrant plus a CDK4/6 inhibitor. The phase-3, randomized, investigator-initiated, nationwide SONIA trial included 1,050 premenopausal and postmenopausal women with hormone receptor-positive, HER2-negative, advanced breast cancer receiving treatment across 74 Dutch hospitals. Moreover, these agents come with added toxicity and costs, and many patients have lasting disease remission on endocrine therapy alone.” “While absolute improvement in first-line studies was larger than in second-line studies, only a minority of patients in the control arm of first-line studies crossed over to receive CDK4/6 inhibitors in the second-line setting. Sonke, MD, P h D, researcher at Netherlands Cancer Institute, told Healio. However, comparative data are lacking to help clinicians decide if CDK4/6 inhibitors should be added to first- or second-line endocrine therapy,” Gabe S. “CDK4/6 inhibitors have been shown to improve outcomes for women with estrogen receptor-positive HER2-advanced breast cancer. The findings, presented at ASCO Annual Meeting, suggested second-line cyclin-dependent kinase (CDK)4/6 inhibitors may be the preferred treatment option for most patients. second-line use when added to endocrine therapy for women with hormone receptor-positive, HER2-negative, advanced breast cancer. The results challenge the need for first-line use of CDK4/6 inhibitors.ĬHICAGO - First-line use of cyclin-dependent kinase 4/6 inhibitors did not confer significant benefit vs.CDK4/6 inhibitors in the earlier setting did not lead to statistically significant PFS or OS improvement.If you continue to have this issue please contact to Healio Key takeaways: Further research is warranted to understand how to maximize communication strategies so that they are the most effective in influencing behaviors and if these results are consistent with other linguistic populations.We were unable to process your request. This was the first study of message effects of breast cancer communication with Italian-speaking young women. For both message types, videos had a more positive influence than infographics when communicating breast cancer information for this audience. The didactic message delivered in video format had the most positive effect on awareness and knowledge, whereas the narrative video message had the most positive effect on attitude and intention. Positive increases were found for all outcome variables after exposure to any communication strategy tested. A total of 194 Italian-speaking women ages 18-30 years completed questionnaires before and after exposure. The effects of the communication strategies were tested using an experimental design with a control group and four experimental groups: narrative video, didactic video, narrative infographic, or didactic infographic. It further aimed to test whether any differences in outcomes were associated with the format used to deliver the communication: video or infographic. This study aimed to measure differences between narrative and didactic communication on breast cancer awareness, knowledge of appropriate diagnostic exams, attitude toward breast self-exam, and intention to screen for breast cancer through a breast self-exam. It is important to find effective communication that encourages early detection of breast cancer. Mortality from breast cancer can be reduced if the cancer is detected early enough. Cancer is one of the leading causes of death around the world.
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